01 / IDENTITY
Compound Profile
Pre-Mixed Blend Advantage: This vial contains both CJC-1295 No DAC and Ipamorelin pre-formulated at a 1:1 ratio. Single injection delivers both molecules simultaneously — maximizing pulsatile GH amplitude while minimizing injection frequency. The gold standard GH secretagogue protocol in one pen draw.
CJC-1295 No DAC
MODIFIED GRF(1-29) · 29 AA · ~3.37 kDa
AMPLIFIER
MECHANISM
GHRH receptor agonist. Signals pituitary to produce and release GH. Short half-life (30 min) preserves physiological pulsatile pattern.
WHAT IT DOES
Loads the pituitary somatotrophs with GH — primes them for maximum release upon GHSR stimulation.
Ipamorelin
SELECTIVE GHRP · 5 AA · ~0.71 kDa
TRIGGER
MECHANISM
GHSR-1a (ghrelin receptor) agonist. Triggers the GH pulse release — selectively, without spiking cortisol, prolactin, or ACTH.
WHAT IT DOES
Pulls the trigger on GH release from the loaded pituitary. The most selective GHRP available — zero off-target hormones.
02 / SYNERGY MECHANISM
Why This Combination Works
2–4×
GH PULSE AMPLITUDE
CJC-1295 + Ipamorelin in combination produces 2–4× the GH pulse amplitude of either compound alone. Two separate receptor pathways (GHRH-R + GHSR-1a) act synergistically on the same pituitary somatotroph cell — the combined signal is multiplicative, not additive.
0
CORTISOL / PROLACTIN ELEVATION
Ipamorelin's selectivity for GHSR-1a means the amplified GH pulse carries none of the cortisol or prolactin side effects seen with GHRP-6 or GHRP-2. Maximum GH output. Zero stress hormone co-activation.
30m
CJC-1295 HALF-LIFE (NO DAC VERSION)
Short half-life preserves the pulsatile GH pattern that mimics natural physiology. GH surges, then clears — allowing IGF-1 to reset between doses. This is critical: continuous GH (DAC version) desensitizes receptors. Pulsatile GH keeps receptors sensitive and IGF-1 in optimal range.
Analogy: CJC-1295 fills the pituitary's GH "tank." Ipamorelin opens the valve. Together — massive, clean, physiological GH pulse. Then it clears. Then you repeat. This is why this stack is called the gold standard of GH optimization.
03 / BENEFITS
Research-Supported Effects
BODY COMPOSITION
Elevated GH drives lipolysis (fat breakdown) and promotes lean mass retention during caloric deficit. Visceral fat preferentially reduced.
SLEEP QUALITY
GH secretion peaks during slow-wave sleep (Stage 3). Bedtime dosing amplifies the natural nocturnal pulse — deeper sleep, more restorative recovery.
RECOVERY
GH stimulates collagen synthesis, tendon repair, and muscle protein synthesis. Injury recovery accelerated. Connective tissue integrity maintained over long cycles.
ANTI-AGING
GH declines ~14% per decade after age 30 (somatopause). Secretagogue protocols restore youthful GH pulsatility without exogenous GH risks. IGF-1 optimizes in age-appropriate range.
SKIN & COLLAGEN
GH-stimulated IGF-1 drives dermal collagen production, skin thickness, and elasticity. Visible improvement typically noted at 8–12 weeks of consistent dosing.
COGNITIVE CLARITY
GH receptors are expressed in the brain. GH optimization associated with improved working memory, mood stability, and energy. Often reported as "mental sharpness" by users.
04 / RECONSTITUTION
Vial Preparation
BLEND VIAL — 5mg TOTAL (2.5mg CJC + 2.5mg Ipamorelin)
5mg blend vial + 3.0 mL (300 units) bacteriostatic water
Concentration: 16.7 mcg per unit (0.01 mL) — TOTAL BLEND
= 8.35 mcg CJC-1295 + 8.35 mcg Ipamorelin per unit
| DOSE LEVEL |
TOTAL BLEND |
UNITS ON SYRINGE |
VOLUME |
BREAKDOWN |
| LOW |
167mcg blend |
10 units |
0.10 mL |
~83mcg CJC + 83mcg IPA |
| STANDARD |
250mcg blend |
15 units |
0.15 mL |
~125mcg CJC + 125mcg IPA |
| HIGH |
400mcg blend |
24 units |
0.24 mL |
~200mcg CJC + 200mcg IPA |
Blend vs. Separate Vials: Pre-blended vials are identical in effect to separate CJC-1295 No DAC + Ipamorelin injections drawn and administered simultaneously. The blend format reduces injection count to one and simplifies preparation. Recommended for all users running the stack.
Storage: Lyophilized powder stable at room temp up to 6 months. After reconstitution: refrigerate (2–8°C), use within 28 days. Protect from light. Do NOT freeze reconstituted solution.
05 / DOSING PROTOCOL
Administration Schedule
| PROTOCOL |
DOSE |
TIMING |
USE CASE |
| ENTRY |
167mcg blend / injection |
Once daily — bedtime |
First cycle, conservative start. Assess GH response. |
| STANDARD |
250mcg blend / injection |
Once daily — bedtime fasted |
Most users. Best balance of effect vs. cost vs. IGF-1 optimization. |
| ADVANCED |
250mcg × 2 / day |
Bedtime + morning fasted |
2x/day protocol. AM pulse for body comp, PM pulse for recovery/sleep. |
| HIGH OUTPUT |
400mcg blend / injection |
Once daily — bedtime |
Experienced users seeking maximum GH pulse. Monitor IGF-1 closely. |
06 / TIMING & ADMINISTRATION
Injection Windows
PRIMARY — BEDTIME
30–60 min before sleep
SECONDARY — MORNING
Fasted · 2x/day protocol only
FASTED STATE
MANDATORY · 2–3h post-meal
WHY BEDTIME IS PRIMARY
80% of natural GH secretion occurs during sleep (especially Stage 3). Dosing 30–60 min before sleep aligns the secretagogue-induced pulse with the body's existing GH architecture. Amplify what's already happening — don't fight circadian biology.
WHY FASTED IS MANDATORY
Insulin directly inhibits GH release. Eating → insulin spike → GH signal blocked at pituitary level. For best results: no food for 2–3 hours before injection. Wait 30 min post-injection before eating (morning protocol).
AVOID CARBS PRE-INJECTION
Even modest carbohydrate intake raises insulin enough to blunt GH response 40–60%. If bedtime snacking is habitual, time it 2+ hours before injection.
DO NOT INJECT POST-WORKOUT
Post-workout GH is already elevated from exercise. Injecting at this window wastes the dose and may create receptor accommodation. Reserve injections for fasted/sleep windows.
07 / BIOMARKER MONITORING
Recommended Lab Panel
GH AXIS — PRIMARY RESPONSE
| MARKER | CLINICAL RANGE | OPTIMAL TARGET | NOTES |
|---|
| IGF-1insulin-like growth factor 1 |
CLINICALAge-adjusted |
OPTIMAL200–350 ng/mL |
Primary readout of GH axis activity. Check at 6 weeks, then every 8–12 weeks. Should be in upper quartile for age. |
| GH (fasting AM)growth hormone — serum |
CLINICAL0–10 ng/mL |
OPTIMAL1–5 ng/mL (basal) |
Fasting AM basal GH — not a pulse measurement. Use as baseline. Pulsatile GH is not captured by standard draw. |
SAFETY MONITORING
| MARKER | CLINICAL RANGE | OPTIMAL TARGET | NOTES |
|---|
| Fasting Glucoseblood glucose |
CLINICAL70–99 mg/dL |
OPTIMAL72–90 mg/dL |
Should remain stable. Elevated GH at supraphysiological levels can cause transient IR. Monitor. |
| Fasting Insulininsulin |
CLINICAL2–25 µIU/mL |
OPTIMAL3–8 µIU/mL |
Track alongside glucose for HOMA-IR calculation. Stability confirms appropriate GH dosing. |
| Cortisol (AM)serum cortisol |
CLINICAL6–23 µg/dL |
OPTIMAL10–18 µg/dL |
Should be UNCHANGED — confirms Ipamorelin selectivity. If elevated, check other stack components. |
| Prolactinserum prolactin |
CLINICAL2–18 ng/mL (M) / 2–29 ng/mL (F) |
OPTIMALBaseline |
Should be unchanged — verifies Ipamorelin's GHSR-1a selectivity (GHRP-6 elevates prolactin; Ipamorelin does not) |
BODY COMPOSITION TRACKING
| MARKER | METHOD | NOTES |
|---|
| Body CompositionDEXA or InBody scan |
Baseline → 8 weeks → 16 weeks |
Lean mass gain + visceral fat reduction. DEXA is gold standard; InBody is practical alternative. |
| Collagen BiomarkersP1NP (procollagen) |
Optional — quarterly |
Elevated P1NP confirms GH-driven collagen synthesis. Validates connective tissue response. |
08 / CYCLE PROTOCOL
Administration Schedule
MINIMUM EFFECTIVE CYCLE
8 weeks — IGF-1 elevation takes 4–6 weeks to stabilize. Most benefits (body comp, sleep, skin) become measurable at 12+ weeks.
FREQUENCY
7 days/week — or 5 days on / 2 off (weekend break). Both effective. Daily dosing is more consistent; 5/2 reduces cost without major efficacy loss.
OFF PERIOD
Some practitioners run year-round at low dose (125–167mcg). If cycling: 4–8 weeks off allows pituitary sensitization reset.
ADVANCED STACKS
+ BPC-157 500mcg (recovery and GI) · + DSIP 250mcg bedtime (deepens SWS + synergistic GH pulse) · + Ibutamoren MK-677 (oral GH secretagogue to extend GH window) · + AOD-9604 500mcg AM (adds targeted lipolysis)
DSIP SYNERGY
DSIP + CJC/Ipamorelin blend is the ultimate sleep stack. DSIP promotes Stage 3 sleep (when GH releases); CJC/Ipa amplifies the GH pulse. The combination creates a virtuous cycle of deeper sleep → larger GH burst → better recovery.
REQUIRES
Reconstitution with BAC water · Precise dosing with Apex V3 Pen · Refrigeration post-reconstitution · Fasted injection window
⚠ Research reference only. CJC-1295 No DAC and Ipamorelin are not FDA-approved for human therapeutic use. Information sourced from published clinical and preclinical literature. Consult a qualified medical provider before use.